MOLECULAR PATHWAYS IDENTIFIED FROM SINGLE NUCLEOTIDE POLYMORPHISMS DEMONSTRATE MECHANISTIC DIFFERENCES IN SYSTEMIC LUPUS ERYTHEMATOSUS PATIENTS OF ASIAN AND EUROPEAN ANCESTRY

Molecular pathways identified from single nucleotide polymorphisms demonstrate mechanistic differences in systemic lupus erythematosus patients of Asian and European ancestry

Abstract Systemic lupus erythematosus (SLE) is a multi-organ autoimmune disorder with a prominent genetic component.Individuals of Asian-Ancestry (AsA) disproportionately experience more severe SLE compared to individuals of European-Ancestry (EA), including increased renal involvement and tissue damage.However, the mechanisms underlying elevated s

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Transcriptomic and functional analyses reveal an antiviral role of autophagy during pepper mild mottle virus infection

Abstract Background Pepper mild mottle virus (PMMoV) is a member in the genus Tobamovirus and infects mainly solanaceous plants.However, the mechanism of virus-host interactions remains unclear.To explore the responses of pepper plants to PMMoV infection, we analyzed the transcriptomic changes in pepper plants after PMMoV infection using a high-thr

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